Seminarium Oddziału Fizykochemii Biomedycznej
Microsoft Teams
Regenerate tissues one at a time
Dr Yadong Wang, Professor of Heart Assist Technology
Meinig School of Biomedical Engineering, Cornell University
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The seminar will be held remotely using Microsoft Teams. People in the intibs.pl domain can join the Seminarium OFB team using the code: 7aoxdkd. Other persons are asked to contact us at
Abstract:
In this talk, it will be presented the extracellular matrix (ECM) guides cells through mechanical and soluble signals among others. We guide cell behaviors using these two aspects of ECM. Many tissues in our body are elastic, including blood vessels, our target tissue. We design biodegradable elastomers for vascular grafts. The hosts transform the degradable grafts into autologous vascular conduits within a few months, performing the duties of a native artery. On soluble factors, we mimic the anchorage of cytokines in the ECM with heparin-based coacervate. The coacervate extends the bioactivity of many cytokines and growth factors. This controlled release platform shows promise in promoting angiogenesis and controlling immune activities. We are currently exploring how these materials perform in preclinical models. The knowledge will guide clinical translation of these materials.
Yadong Wang is the McAdam Family Foundation Professor at Cornell University. He obtained his Ph.D. degree at Stanford University in 1999, conducted his postdoctoral research at MIT, and joined the Georgia Institute of Technology in 2003 as an assistant professor. He was recruited to the University of Pittsburgh in 2008 and to Cornell in 2017. He has published on topics ranging from Chemistry, Materials Science to Biomedical Engineering. He is a fellow of American Institute for Medical and Biological Engineering and the National Academy of Inventors. His research focuses on the design and application of biomaterials. Several of his inventions are licensed, one of which is commercially available and approved for clinical use. He co-founded three companies, one of which is marketing advanced medical adhesives.
