Wykład w ramach WSD IPAN

Luminescent nanocrystals as multifunctional diagnostic tools - Part 2 of 2

dr hab. Łukasz Marciniak, prof. instytutu

INTiBS PAN

Remote lecture using the Microsoft Teams application. If you are interested, please contact dr Adam Watras ()

Wykład zdalny przy pomocy aplikacji Microsoft Teams. Osoby zainteresowane proszone są o kontakt z dr. Adamem Watrasem ()

Abstract:

The phenomenon of luminescence has fascinated mankind for centuries. The development of nanotechnology has made it possible to develop nanosized luminescent objects. This has served not only to study and understand of physical processes occurring at the nanoscale, but above all, it has enabled the use of such particles as biological luminescent markers and nanoscale sensors of changes in physical and chemical parameters in vitro and in vivo. The nanoscaled luminescence thermometers, manometers, and indicators of pH changes could bring medical diagnostics into a new era of rapid readout at the cellular level. In addition, due to the semi-invasive operating mode, luminescent functional nanoparticles offer the possibility of in-real-time remote sensing of physical quantities in a feedback loop which is particularly important from the perspective of targeted therapies and controlled local drug delivery. Therefore, the efforts of many research groups around the world are directed towards the development of new materials and imaging methodologies to increase the precision and accuracy of luminescence-based diagnostics.

The purpose of this lecture is to introduce the student to the fundamentals of physical processes used in noncontact pressure, temperature, and pH sensing with a special emphasis on inorganic materials doped with lanthanide and transition metal ions. Examples of applications of luminescent nanomaterials in diagnostics will be discussed, taking into account both pioneering work and recent scientific achievements.