Breaking the Limits of Sugar Sensing in Plants Using Photon Avalanche FRET
TYTUŁ PROJEKTU: Breaking the Limits of Sugar Sensing in Plants Using Photon Avalanche FRET
TYP PROJEKTU: Human Fronter Science Programme (HFSP) - https://www.hfsp.org/
NUMER PROJEKTU: RGP011/2026
KIEROWNIK PROJEKTU po stronie PL: prof. dr hab. Artur Bednarkiewicz
PARTNERZY PROJEKTU: prof. Niko Hildebrandt - McMaster University - Hamilton - CANADA
prof. Wolf B. Frommer - Heinrich Heine University Dusseldorf - Düsseldorf – GERMANY
STRESZCZENIE PROJEKTU:
Fluorescent biosensors are of paramount importance for investigating signaling and metabolism in multicellular organisms, e.g., synthesis, transport, degradation and signaling of metabolites, energy production, development, and defense against pathogens. Currently used biosensors heavily rely on fluorescent proteins, which have significant drawbacks concerning their photophysical performance. The main goal of our project is the development of a new nanoparticle-based biosensing technology for real-time intra- and extra-cellular quantification of extremely small changes of metabolites, which is not possible with currently available methods. Realizing our challenging project goal at the interface of physics, chemistry, and biology requires an international team of experts in synthesis and optical characterization of nanoparticles (Artur Bednarkiewicz, Poland), nanoparticle bioconjugation and biosensing (Niko Hildebrandt, Canada), and the analysis of transport and signaling in plants (Wolf Frommer, Germany). Our interdisciplinary and collaborative approach covers all aspects from the experimental proof-of-concept, over the implementation into advanced biosensing approaches, to the translation into real-life analysis of molecular mechanisms in plant physiology with a focus on real-time sugar sensing. Our new technology will move the frontiers of metabolite analysis in plants and the method will be directly transferable into the analysis of many other biomolecular interactions in life and health sciences.
WARTOŚĆ PROJEKTU po stronie PL: 400 000 $
OKRES REALIZACJI PROJEKTU: 01.10.2026 - 30.09.2029
